Thermo Fisher Scientific IRE1 alpha Monoclonal Antibody (J.607.10)
IRE1 alpha 단백질을 인식하는 Rabbit Monoclonal Antibody (Clone J.607.10). Western blot, IP, RIP에 사용 가능. Human 및 Mouse 반응성. 고순도 Affinity 정제, -20°C 보관. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | - |
| RNA Immunoprecipitation (RIP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.607.10 |
| Immunogen | Synthetic peptide corresponding to residues surrounding His963 of human IRE1α |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 108 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10977010 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
ERN1 (serine/threonine kinase) or endoplasmic reticulum to nucleus signaling 1 is a human homologue of the yeast Ire1 gene product, possessing intrinsic kinase and endoribonuclease activity. It plays a key role in ER-based stress signaling, controlling IRE1 proteolysis in mammalian cells and being essential for fetal viability.
IRE1 acts as a sensor of unfolded proteins in the ER, initiating signal transduction to the nucleus by splicing XBP1 mRNA to produce a potent transcriptional activator of the unfolded protein response.
Null mutants are viable but essential under stress conditions that cause unfolded protein accumulation in the ER. Expression of a dominant negative form of IRE1p leads to apoptosis under such stress conditions.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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