Thermo Fisher Scientific Glutamine Synthetase Monoclonal Antibody (CL3004)
Glutamine Synthetase 단백질을 인식하는 Mouse monoclonal 항체. WB 및 IHC(P)에서 검증됨. Protein A로 정제된 액상 형태이며, PBS buffer(40% glycerol, 0.02% sodium azide) 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL3004 |
| Immunogen | Recombinant protein corresponding to Human Glutamine Synthetase (UniProt ID: P15104-1, antigen range: 68–208) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848911 |
Product Specific Information
Immunogen sequence:
LQSEGSNSDM YLVPAAMFRD PFRKDPNKLV LCEVFKYNRR PAETNLRHTC KRIMDMVSNQ HPWFGMEQEY TLMGTDGHPF GWPSNGFPGP QGPYYCGVGA DRAYGRDIVE AHYRACLYAG VKIAGTNAEV MPAQWEFQIG P
Target Information
Glutamine synthetase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthetase. Glutamate plays a central role in mammalian nitrogen flow, serving as both a nitrogen donor and acceptor. It also has an important role in controlling metabolic regulation of the neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation and is decreased in the cerebral cortex of brains affected by Alzheimer’s disease, particularly near senile plaques. It is also decreased under conditions of glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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