Thermo Fisher Scientific DUSP14 Polyclonal Antibody
Human DUSP14 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer와 glycerol 포함. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DUSP14. Recombinant protein control fragment (Product #RP-91567) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789862 |
Product Specific Information
Immunogen sequence:
LPRTLMAPRM ISEGDIGGIA QITSSLFLGR GSVASNRHLL QARGITCIVN ATIEIPNFNW PQFEYVKVPL ADMPHAPIGL YFDTVADKIH SVS
Target Information
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells.
CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through activation of mitogen-activated protein kinases (MAPKs), such as ERK (MAP2K4; MIM 601335) and JNK (MIM 601158), leading to formation of AP1 transcription factor (MIM 165160).
DUSP14 acts as a negative regulator of CD28 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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