Thermo Fisher Scientific GAS2L1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal Antibody로, GAS2L1 단백질 검출에 적합. Western Blot, IHC, ICC/IF 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체. 연구용으로만 사용.
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Thermo Fisher Scientific GAS2L1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GAS2L1. Recombinant protein control fragment (Product #RP-108158) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789860 |
Product Specific Information
Immunogen sequence:
RLSRVSSPSP ELGTTPASIF RTPLQLDPQQ EQQLFRRLEE EFLANARALE AVASVTPTGP APDPARAPDP PAPDSAYCSS SSSSSSLSVL GGKCG
Target Information
The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by caspase-3 or caspase-7 at Asparagine 278 during apoptosis. The cleaved form of Gas2 induces rearrangement of the Actin cytoskeleton and changes in cell morphology. Gas2 co-localizes with Actin fibers at the cell border and along stress fibers in growth-arrested fibroblasts. It is mainly membrane-associated but accumulates at membrane ruffles when hyperphosphorylated, suggesting involvement in that process. Gar22 (Gas2-related protein on chromosome 22), also known as Gas2-like1 (Gas2L1), belongs to the Gas2 family and contains one CH (calponin homology) domain, contributing to cross-linking of microtubules and microfilaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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