Thermo Fisher Scientific PGR Monoclonal Antibody (OTI15C1), TrueMAB
프로게스테론 수용체(PGR)를 인식하는 마우스 단클론 항체. Western blot에 최적화되어 있으며, 인체 단백질(aa 1-298)을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15C1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, a hormone critical for reproductive events such as the establishment and maintenance of pregnancy.
PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), produced via alternative translation initiation sites.
- PR-B: Transcriptionally active form responsible for maintaining the endometrium and pregnancy, and inhibiting ovulation.
- PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, which exposes a 140 amino acid inhibitory domain (ID) that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational changes, dimerizes, and binds to progesterone response elements (PRE), activating gene transcription.
A null mutation in the PGR gene results in pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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