Thermo Fisher Scientific Phospho-CHK1 (Ser286) Polyclonal Antibody
Phospho-CHK1 (Ser286) 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 응용(WB, IHC, ICC, ELISA)에 사용 가능하며, Human 및 Mouse 반응성. 고순도 Protein A 정제 및 안정적인 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthesized phosphopeptide derived from human CHEK1 around the phosphorylation site of Ser286 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment, particularly since about 50% of human cancers are p53-deficient.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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