Thermo Fisher Scientific Caspase 6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-1.5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence NRKVSQRRVDFCKDP (aa 253-267). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Caspase 6,uniProtId:P55212-1,ncbiNodeId:9606,antigenRange:253-267,antigenLength:293,antigenImageFileName:PA5-143078_Caspase_6_P55212-1_Goat.svg,antigenImageFileNamePDP:PA5-143078_Caspase_6_P55212-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2933717

Product Specific Information

Additional Information: This antibody is expected to recognize reproted isoform alpha (NP_001217.2) only. The immunizing peptide overlaps phosphorylated serine 257 and therefore this antibody is not expected to recognize the phosphorylated protein.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.