Thermo Fisher Scientific CYP1A2 Monoclonal Antibody (OTI1H3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The CYP1A2 protein localizes to the endoplasmic reticulum, and its expression is induced by polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
The enzyme’s endogenous substrate is unknown but can metabolize certain PAHs into carcinogenic intermediates. Other substrates include caffeine, aflatoxin B1, and acetaminophen. The transcript contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.