Thermo Fisher Scientific AHNAK Monoclonal Antibody (EM-09)
AHNAK1 단백질을 인식하는 EM-09 클론의 Mouse Monoclonal Antibody. Western blot, IHC(F), ICC/IF, IP에 사용 가능. Human 및 Mouse 반응성. Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공. 4°C에서 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-09 |
| Immunogen | Bacterially expressed fragment of N-terminal domain of human AHNAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156613 |
Product Specific Information
This antibody reacts with AHNAK1, a 700 kDa multifunctional adaptor protein expressed mainly in epithelial cells, various types of muscle cells, and immune cells.
For immunocytochemistry, permeabilization is required.
Target Information
AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increase in extracellular calcium level or upon protein kinase C activation. It regulates extracellular calcium influx mediated by L-type Ca²⁺ channels and is implicated in diverse signal transduction processes affecting cell differentiation and proliferation.
In response to calcium-dependent intercellular contacts, AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies, contributing to plasma membrane architecture.
In epithelial cells, AHNAK1 is localized in the cytoplasm or membrane-associated, while in non-epithelial cells it is predominantly nuclear, showing weak DNA-binding activity and association with the DNA-ligase IV–XRCC4 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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