Thermo Fisher Scientific AHNAK Monoclonal Antibody (EM-09)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody reacts with AHNAK1, a 700 kDa multifunctional adaptor protein expressed mainly in epithelial cells, various types of muscle cells, and immune cells.
For immunocytochemistry, permeabilization is required.

Target Information

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increase in extracellular calcium level or upon protein kinase C activation. It regulates extracellular calcium influx mediated by L-type Ca²⁺ channels and is implicated in diverse signal transduction processes affecting cell differentiation and proliferation.
In response to calcium-dependent intercellular contacts, AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies, contributing to plasma membrane architecture.
In epithelial cells, AHNAK1 is localized in the cytoplasm or membrane-associated, while in non-epithelial cells it is predominantly nuclear, showing weak DNA-binding activity and association with the DNA-ligase IV–XRCC4 complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.