Thermo Fisher Scientific beta-2 Microglobulin Monoclonal Antibody (B2M-02), Biotin
Human 및 Pig 반응성의 beta-2 Microglobulin 단클론 항체로, Biotin으로 표지되어 있습니다. Western blot, IHC, Flow cytometry, ELISA에 사용 가능하며, PBS 기반 용액 형태로 제공됩니다. 4°C에서 보관하며 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B2M-02 |
| Immunogen | Purified isolated human beta2-microglobulin |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154984 |
Additional Formats
Product Specific Information
This antibody reacts with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig-like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms a subunit of the major histocompatibility complex (MHC) class I. It is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes.
It is found in free form in plasma and has a structure homologous to immunoglobulin constant regions. Beta-2-microglobulin is involved in antigen processing and presentation, TCR signaling, and CD8+ T-cell signaling.
Encoded by the B2M gene on chromosome 15, mutations can cause hypercatabolic hypoproteinemia. Beta-2 microglobulin levels are used as a marker for renal function and as a prognostic marker in HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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