Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), eFluor 660, eBioscience

Applications and Tested Dilution

Product Specifications

Additional Available Formats

• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Yellow 660
• NovaFluor Yellow 730
• NovaFluor Yellow 755
• PE
• PerCP-eFluor 710
• Super Bright 600
• Request custom conjugation

Product Specific Information

The A2MR-a2 monoclonal antibody reacts with human CD91, also known as LRP-1 and alpha-2 macroglobulin receptor. CD91 is a 600 kDa type I transmembrane protein consisting of alpha and beta chains. The alpha chain binds multiple structurally and functionally diverse ligands, while the beta chain contains tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. Ligand binding mediates endocytosis and lysosomal trafficking.

This receptor is expressed by monocytic lineage cells, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 contributes to cross-presentation of antigens via MHC class I molecules and plays roles in cell migration and signaling activation.

Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometry on normal human peripheral blood cells. Recommended usage: 5 µL (0.06 µg) per 100 µL test volume, with 10⁵–10⁸ cells/test.

Fluorophore Information:
eFluor™ 660 replaces Alexa Fluor™ 647. It emits at 659 nm and is excited with the red laser (633 nm). Ensure instrument compatibility.

• Excitation: 633–647 nm
• Emission: 668 nm
• Laser: Red Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

The encoded protein is an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is also required for A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques in Alzheimer’s disease. Expression decreases with age and is lower in Alzheimer’s brain tissue compared to controls.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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