Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), eFluor 660, eBioscience
CD91 단백질을 인식하는 A2MR-a2 단클론 항체로, eFluor 660 형광 표지되어 있습니다. 인간 CD91 발현 세포의 유세포분석(Flow Cytometry)에 적합합니다. 633 nm 레이저로 여기되며, 668 nm에서 방출됩니다. 연구용으로만 사용 가능합니다.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), eFluor 660, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1 µg/mL | - |
| Flow Cytometry (Flow) | 5 µL (0.06 µg)/test | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2MR-a2 |
| Conjugate | eFluor™ 660 |
| Excitation/Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574176 |
Additional Available Formats
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Yellow 660
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PerCP-eFluor 710
- Super Bright 600
- Request custom conjugation
Product Specific Information
The A2MR-a2 monoclonal antibody reacts with human CD91, also known as LRP-1 and alpha-2 macroglobulin receptor. CD91 is a 600 kDa type I transmembrane protein consisting of alpha and beta chains. The alpha chain binds multiple structurally and functionally diverse ligands, while the beta chain contains tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. Ligand binding mediates endocytosis and lysosomal trafficking.
This receptor is expressed by monocytic lineage cells, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 contributes to cross-presentation of antigens via MHC class I molecules and plays roles in cell migration and signaling activation.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometry on normal human peripheral blood cells. Recommended usage: 5 µL (0.06 µg) per 100 µL test volume, with 10⁵–10⁸ cells/test.
Fluorophore Information:
eFluor™ 660 replaces Alexa Fluor™ 647. It emits at 659 nm and is excited with the red laser (633 nm). Ensure instrument compatibility.
- Excitation: 633–647 nm
- Emission: 668 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
The encoded protein is an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is also required for A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques in Alzheimer’s disease. Expression decreases with age and is lower in Alzheimer’s brain tissue compared to controls.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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