Thermo Fisher Scientific PKC Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

• Positive control: SKBR-3 cells
• Cellular location: Cytoplasmic

Target Information

Protein Kinase C (PKC) is a multifunctional protein kinase that plays a critical regulatory role in a wide variety of cellular signaling processes. It is a ubiquitous calcium and phospholipid-dependent protein kinase.
At least 10 PKC isoforms are reported to exist, classified as conventional, novel, and atypical isoforms (Ohno and Nishizuka, 2002).
PKC is one of the three major protein kinases (including CaM Kinase II and PKA) that mediate cellular responses to second messengers.
It regulates numerous cellular functions including neurotransmitter synthesis and release, gene expression, ion channel function, and synaptic plasticity (Lu et al., 1999; Grosshans et al., 2002; Nishizuka, 1995).
The catalytic fragment of PKC (PKC-M) does not require Ca²⁺ or phosphatidylserine for its activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: 500-9234_PKC_Q05513-1_Rabbit.svg / 500-9234_PKC_Q05513-1_Rabbit_PDP.jpeg)