Thermo Fisher Scientific Alkaline Phosphatase (Placental)/PLAP (Germ Cell Tumor Marker) Recombinant Rabbit Monoclonal Antibody (ALPP/9109R)
인체 PLAP 단백질을 인식하는 Recombinant Rabbit Monoclonal 항체로, 생식세포 종양 표지자 연구에 적합. IHC(P)에서 1–2 µg/mL로 사용 가능. JEG-3, HepG2, 태반, seminoma 조직에 양성 대조로 추천. PBS/BSA buffer에 보존, 4°C 보관.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ALPP/9109R |
| Immunogen | Recombinant full-length human ALPP protein (Placental Alkaline Phosphatase, UniProt ID: P05187-1, amino acids 1–535) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: JEG-3 or HepG2 cells, human placenta, or seminoma
- Cellular Location: Cytoplasm and cell surface
Target Information
Placental Alkaline Phosphatase (PLAP) plays a key role in regulating specific inflammatory processes. There are four related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney types. PLAP is a membrane-bound isoenzyme (Regan and Nagao type) expressed in the placenta during the third trimester of gestation and is a useful marker for identifying testicular germ cell tumors.
Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
A proposed function of PLAP is matrix mineralization; however, mice lacking functional PLAP exhibit normal skeletal development.
PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects, with severity depending on specific mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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