Thermo Fisher Scientific MUC1 Monoclonal Antibody (OTI2E3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:4,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic lineages.
It is a transmembrane glycoprotein with a large extracellular domain containing numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic, with alleles encoding different repeat numbers (30–90), leading to variable molecular weights.
It is abundantly expressed in >90% of breast carcinomas and metastases.
Overexpression and aberrant localization are associated with carcinomas.
Multiple alternatively spliced transcript variants encode distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.