Thermo Fisher Scientific MAPKAP1 Polyclonal Antibody
MAPKAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용 가능. Human, Mouse, Rat 반응성 보유. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. 세포 성장 및 신호전달 연구에 적합.
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Thermo Fisher Scientific MAPKAP1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the amino terminus of human MAPKAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154989 |
Product Specific Information
- Suggested positive control: human skeletal muscle tissue lysate
- PA5-20361 can be used with blocking peptide PEP-0586
Target Information
Sin1 was initially identified as the human homolog of S. pombe SIN1. It is identical to Mip1, a protein interacting with MEKK2, a member of the MAPK signaling network.
MAPKAP1 prevents MEKK2 activation and dimerization by forming a complex with inactive MEKK2, blocking JNK1/2, ERK1/2, p38, and ERK5 MAPKs.
It also plays a role in the TOR signaling pathway, regulating cell growth and proliferation in response to nutrients and growth factors.
MAPKAP1 helps maintain the TOR/rictor assembly, allowing specific phosphorylation of Akt, linking PI3K signaling to TOR signaling.
Multiple alternatively spliced isoforms of MAPKAP1 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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