Thermo Fisher Scientific DARC Polyclonal Antibody
Rabbit Polyclonal DARC 항체로 Western blot, IHC, ICC/IF에 사용 가능. Human 시료 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체. PBS buffer, sodium azide 함유. ACKR1/DARC 단백질 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.25–0.5 µg/mL | - |
| Immunohistochemistry (IHC) | 5 µg/mL | 1 publication |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human DARC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152655 |
Product Specific Information
- A suggested positive control is PC-3 cell lysate.
- PA5-20360 can be used with blocking peptide PEP-0585.
Target Information
ACKR1 (also known as DARC) is an atypical chemokine receptor that regulates chemokine levels and localization via high-affinity chemokine binding, independent of classical signal transduction. It functions as a chemokine interceptor or scavenger receptor, binding inflammatory chemokines from both CXC and CC subfamilies but not homeostatic chemokines.
ACKR1 also serves as a receptor for chemokines such as CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC, and for malaria parasites P. vivax and P. knowlesi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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