Thermo Fisher Scientific Human Cytokeratin 18 Recombinant Protein

Thermo Fisher Scientific Human Cytokeratin 18 Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

This product contains purified recombinant human Cytokeratin-18 protein with an N-terminal hexahistidine tag.
It may be used as a positive control in many immunological assays.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
Tissues from gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells, are positive for cytokeratin 18.
It is found primarily in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns are increasingly used to distinguish different types of epithelial malignancies.
Cytokeratin antibodies assist in tumor differential diagnosis via immunohistochemistry, and are also useful in cytopathology and flow cytometric assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.