Thermo Fisher Scientific Human Cytokeratin 18 Recombinant Protein
Recombinant human Cytokeratin 18 단백질로, N-terminal His-tag을 포함하며 >95% 순도(SDS-PAGE 기준)를 가짐. 다양한 면역학적 실험의 양성 대조군으로 사용 가능. 액상 형태이며 -20°C 보관, 동결/해동 반복 피해야 함.
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- RP7553x (3개 옵션)
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- Protein
- 판매단위
- pk
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Thermo Fisher Scientific Human Cytokeratin 18 Recombinant Protein
Applications
- Western Blot (WB): Assay-dependent
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Amino acids Met1–His430 containing an N-terminal His-tag |
| Tag | His-tag |
| Class | Recombinant |
| Type | Protein |
| Purity | >95%, by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.22 mg/mL |
| Purification | Purified |
| Storage Buffer | Tris HCl, pH 8, with 50% glycerol, 5 mM EDTA |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This product contains purified recombinant human Cytokeratin-18 protein with an N-terminal hexahistidine tag.
It may be used as a positive control in many immunological assays.
Target Information
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
Tissues from gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells, are positive for cytokeratin 18.
It is found primarily in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns are increasingly used to distinguish different types of epithelial malignancies.
Cytokeratin antibodies assist in tumor differential diagnosis via immunohistochemistry, and are also useful in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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