Thermo Fisher Scientific BPI Polyclonal Antibody

Applications

• Western Blot (WB): 0.3–1 µg/mL

Product Specific Information

• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Product Specifications

Target Information

The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and also on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI is a bactericidal compound present in polymorphonuclear cells (PMN) and, to a lesser extent, in eosinophil granules. It binds strongly to the lipid A region of lipopolysaccharides (LPS) in gram-negative bacteria, leading to multiple anti-infective effects, including:

• Cytotoxicity via damage to bacterial membranes
• Neutralization of bacterial LPS
• Opsonization enhancing phagocytosis by neutrophils

BPI may play a role in airway diseases triggered by LPS, as airway epithelial cells constitutively express the BPI gene. A recombinant fragment, rBPI21 (21 kDa), has shown protective effects against invasive pneumococcal disease by binding to pneumolysin, a gram-positive bacterial toxin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.