Thermo Fisher Scientific BPI Polyclonal Antibody
인간 BPI 단백질을 인식하는 염소 유래 Polyclonal 항체로, Western blot에 적합합니다. 0.5 mg/mL 농도의 액상 형태이며, TBS(pH 7.3)와 0.5% BSA를 포함합니다. 항균 단백질 BPI 연구 및 LPS 관련 염증 반응 연구에 활용됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BPI Polyclonal Antibody
Applications
- Western Blot (WB): 0.3–1 µg/mL
Product Specific Information
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KIPDYSDSFKIKH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933865 |
Target Information
The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and also on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI is a bactericidal compound present in polymorphonuclear cells (PMN) and, to a lesser extent, in eosinophil granules. It binds strongly to the lipid A region of lipopolysaccharides (LPS) in gram-negative bacteria, leading to multiple anti-infective effects, including:
- Cytotoxicity via damage to bacterial membranes
- Neutralization of bacterial LPS
- Opsonization enhancing phagocytosis by neutrophils
BPI may play a role in airway diseases triggered by LPS, as airway epithelial cells constitutively express the BPI gene. A recombinant fragment, rBPI21 (21 kDa), has shown protective effects against invasive pneumococcal disease by binding to pneumolysin, a gram-positive bacterial toxin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.