Thermo Fisher Scientific ASIC1 Polyclonal Antibody
ASIC1 단백질을 인식하는 Goat Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 IHC(P)에서 검증되었으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. TBS(pH 7.3) 버퍼에 0.5% BSA와 0.02% sodium azide를 포함하며, -20°C 보관이 권장됩니다.
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- PA5143225
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-NILPHHPARGT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933864 |
Product Specific Information
- This antibody is expected to recognize all reported isoforms (NP_064423.2; NP_001086.2; NP_001243759.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop with many cysteine residues of conserved spacing.
The protein is expressed in most brain neurons and may function as an ion channel subunit. It acts as a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺ ions and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampal formation, amygdala, cerebellum, and various basal ganglia regions. Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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