Thermo Fisher Scientific NALP4 Polyclonal Antibody
Thermo Fisher Scientific의 NALP4 Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 rabbit IgG 기반의 다클론 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. NF-kappa-B 신호 조절 연구에 유용합니다.
- 카탈로그번호
- PA521020
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid peptide near the center of human NALP4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152231 |
Product Specific Information
- A suggested positive control is K562 cell lysate.
- PA5-21020 can be used with blocking peptide PEP-1134.
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins, which are involved in inflammation and reproduction.
NALP4, also known as PYRIN-containing APAF1-like protein 4, has:
- A C-terminal leucine-rich repeat (LRR) region
- An N-terminal Pyrin domain (PYD)
- A NACHT domain and a NACHT-associated domain
In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-α and IL-1-β, suggesting that NALP4 operates at a convergence point in these signaling pathways.
NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and kinases (TRAF2, TRAF6, RIP, IRAK2, IKK-α, and IKK-β), indicating its critical role in modulating NF-kappa-B activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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