Thermo Fisher Scientific Lano Polyclonal Antibody
Thermo Fisher Scientific의 Lano 폴리클로날 항체는 인간 Lano 단백질을 인식하며 WB 및 IHC에 적합합니다. Rabbit IgG 기반으로 제작되었으며, 액상 형태로 1 mg/mL 농도입니다. 항원 친화 크로마토그래피로 정제되었고, 2–8°C 보관 시 안정적입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 15 amino acids near the carboxy terminus of human Lano |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151952 |
Product Specific Information
- A suggested positive control is PC-3 cell lysate.
- PA5-19994 can be used with blocking peptide PEP-0116.
Target Information
Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that includes Densin-180, Erbin, and hScribble. LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which target them to the basolateral membrane of epithelial cells.
Lano is unique in that it lacks PDZ domains, unlike other LAP family members. However, it can bind to PDZ domains of Erbin and membrane-associated guanylate kinase (MAGUK) proteins, which regulate adhesion and plasticity at cell junctions. These interactions suggest LAP proteins play roles in embryonic development and epithelial tissue integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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