Thermo Fisher Scientific KChIP3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: CSEN transfected 293T cell, mouse brain
• Predicted reactivity: Mouse (97%), Rat (95%), Rhesus Monkey (98%), Bovine (94%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system.
In the heart, Kv4 channels are involved in the repolarization phase of the action potential.
In the brain, these channels prevent reverse-propagation of action potentials.

Found associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins).
KChIPs bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function.

There are three known KChIPs:

• KChIP1: expressed in the brain
• KChIP2: expressed in brain, heart, and lung (three isoforms: a, b, c)
• KChIP3: also known as calsenilin and DREAM, expressed in brain and testis

KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos.
It is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator.
KChIP3 is also associated with presenilins and implicated in beta-amyloid formation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.