Thermo Fisher Scientific UCH37 Polyclonal Antibody
UCH37 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 적합. 인간 및 랫트 시료 반응성. 1 mg/mL 농도, PBS/glycerol 저장, -20°C 보관. 암 연구 및 단백질 분해 조절 기전 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UCHL5 (Accession Q9Y5K5), corresponding to amino acid residues F165–E215 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852394 |
Product Specific Information
Antibody detects endogenous levels of total UCHL5.
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that edits polyubiquitinated protein substrates. UCH-L5 may rescue ubiquitinated proteins, including oncogenic proteins, from proteasomal degradation, potentially influencing tumor growth. Through association with Smad7, UCH-L5 can upregulate TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in various cancer cell lines, making them potential targets for cancer therapy. Four isoforms of UCH-L5 exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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