Thermo Fisher Scientific NODAL Monoclonal Antibody (4H2)
인간 NODAL 단백질을 인식하는 Mouse IgG2b 단클론 항체로, ELISA에 10 µg/mL 농도로 사용 가능. TGF-beta 계열 단백질 연구 및 암세포 분화, 전이 관련 연구에 적합. 액상 형태로 PBS(pH 7.4)에 보존되며, -20°C에서 보관.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H2 |
| Immunogen | NODAL (NP_060525.3, 180–279 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CWPRPPTPPA TNVLLMLYSN LSQEQRQLGG STLLWEAESS WRAQEGQLSW EWGKRHRRHH LPDRSQLCRK VKFQVDFNLI GWGSWIIYPK QYNAYRCEGE
Target Information
NODAL is an important TGF-beta family protein involved in cellular differentiation. It is constitutively expressed in developing tissues but is also associated with cancer differentiation and progression.
Expression of NODAL is regulated by the Notch signaling pathway, and its disruption contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma.
The abundance of NODAL expression in melanoma can help determine cancer stage and metastatic progression in IHC testing.
NODAL interactions with Cripto promote tumor progression, and overexpression is also associated with preeclamptic placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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