Thermo Fisher Scientific NODAL Monoclonal Antibody (2F1)
인간 NODAL 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, ELISA에 최적화됨. Affinity chromatography로 정제된 액상 형태이며, PBS(pH 7.4)에 보존제 없이 제공됨. 세포 분화 및 암 관련 연구용으로 적합.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F1 |
| Immunogen | NODAL (NP_060525.3, 180 a.a. ~ 279 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
CWPRPPTPPA TNVLLMLYSN LSQEQRQLGG STLLWEAESS WRAQEGQLSW EWGKRHRRHH LPDRSQLCRK VKFQVDFNLI GWGSWIIYPK QYNAYRCEGE
Target Information
NODAL is an important TGF-beta family protein involved in cellular differentiation. It is constitutively expressed in developing tissues but is also associated with the differentiation and development of various cancers. NODAL expression is regulated by the Notch signaling pathway, which, when disrupted, contributes to aggressive metastatic behavior, especially in melanoma. The abundance of NODAL expression can help determine cancer stage and metastatic progression in IHC. NODAL interactions with Cripto are linked to tumor progression, and overexpression is also associated with preeclamptic placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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