Thermo Fisher Scientific SCN9A Monoclonal Antibody (N68/6), PE
SCN9A 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, PE 형광 표지 형식 제공. 다양한 응용 분야(WB, IHC, ICC 등)에 사용 가능하며, 높은 특이성과 재현성을 갖춘 연구용 항체. 인간, 마우스, 랫트 등 다양한 종에 반응.
- 카탈로그번호
- MA545422
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific SCN9A Monoclonal Antibody (N68/6), PE
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N68/6 |
| Immunogen | Fusion protein amino acids 1751–1946 (C-terminus) of human Nav1.7 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931876 |
Additional Formats
Product Specific Information
1 µg/mL of MA5-45422 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 230 kDa. No cross-reactivity against other Nav channels.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share organizational similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region. ENaC isoforms (alpha, beta, gamma) are expressed in kidney, lung, and colon, playing essential roles in sodium and fluid balance. ENaC mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure. It interacts with CFTR chloride channels. Gain-of-function mutations in beta or gamma ENaC can cause Liddle’s syndrome, while loss-of-function mutations in alpha or beta ENaC lead to pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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