Thermo Fisher Scientific SCN9A Monoclonal Antibody (N68/6), FITC
SCN9A 단백질(Nav1.7)을 인식하는 FITC 결합 마우스 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합. 사람, 생쥐, 햄스터, 랫트 반응성. 단백질 G 정제, 1 mg/mL 농도, 4°C 암소 보관. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N68/6 |
| Immunogen | Fusion protein amino acids 1751–1946 (C-terminus) of human Nav1.7 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.09 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931874 |
Additional Formats
- Unconjugated (MA5-27664)
- APC (MA5-45419)
- PE (MA5-45422)
- PerCP (MA5-45421)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45420 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 230 kDa. No cross-reactivity against other Nav channels.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share structural similarities, including two short intracellular termini, two transmembrane segments, and a large extracellular loop with conserved cysteine-rich regions.
ENaC isoforms (α, β, γ) are expressed in kidney, lung, and colon, playing key roles in sodium and fluid balance. They mediate aldosterone-dependent sodium reabsorption in the distal nephron, influencing blood pressure regulation.
Gain-of-function mutations in β- or γ-ENaC can cause Liddle’s syndrome (hypertension), while loss-of-function mutations in α- or β-ENaC lead to pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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