Thermo Fisher Scientific UCH37 Polyclonal Antibody
UCH37 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunoprecipitation에 적합합니다. Human UCH-L5의 150–200 잔기 영역을 면역원으로 제작되었으며, 액상 형태로 1 mg/mL 농도입니다. 4°C 보관, Wet ice 배송.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 to 200 of Human Ubiquitin Carboxyl-Terminal Hydrolase L5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine and Pig
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquitinated protein substrates. Since UCH-L5 can rescue ubiquitinated proteins, including oncogenic proteins, from proteasomal degradation, deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UCH-L5 can upregulate TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI. Overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, suggesting potential therapeutic interest in their inhibition. Four isoforms of UCH-L5 exist due to alternative splicing events.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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