Thermo Fisher Scientific UCH37 Polyclonal Antibody
Thermo Fisher Scientific의 UCH37 Polyclonal Antibody는 인간 UCH-L5 단백질(279–329 aa)을 면역원으로 제작된 rabbit IgG 항체입니다. Western blot 및 Immunoprecipitation에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C 보관, 1년 유효기간.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 279–329 of Human Ubiquitin Carboxyl-Terminal Hydrolase L5 (UCH37) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Predicted to react with Mouse, Bovine, and Pig (based on 100% sequence identity)
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that edits polyubiquitinated protein substrates.
UCH-L5 can rescue ubiquitinated proteins, including oncogenic proteins, from proteasomal degradation, potentially influencing tumor growth.
Associations with Smad7 enable UCH-L5 to upregulate TGFβ-dependent gene expression by deubiquitinating and stabilizing TGFβ RI.
Overexpression of UCH-L5 and related enzymes has been observed in cancer cell lines, suggesting potential therapeutic relevance.
Four isoforms of UCH-L5 exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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