Thermo Fisher Scientific GPM6A Polyclonal Antibody
GPM6A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot과 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며 PBS와 글리세롤 버퍼에 보관. 신경세포 분화 및 신경 가소성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human glycoprotein M6A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635803 |
Product Specific Information
This antibody detects endogenous levels of total GPM6A protein.
Target Information
Neuronal membrane glycoprotein M6-a is encoded by the GPM6A gene in humans. It is involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility, and possibly synapse formation.
GPM6A-induced filopodia formation involves MAPK and Src signaling pathways. It may participate in neuronal NGF-dependent Ca²⁺ influx and regulate endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs), enhancing internalization and recycling of the mu-type opioid receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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