Thermo Fisher Scientific GSTA2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total GSTA2 protein.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic, which can influence susceptibility to carcinogens and toxins and affect drug toxicity and efficacy.

Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class, located in a cluster on chromosome 6. The alpha class enzymes are abundantly expressed in the liver and are involved in metabolizing bilirubin and certain anti-cancer drugs. Additionally, they exhibit glutathione peroxidase activity, protecting cells from reactive oxygen species and peroxidation products.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.