Thermo Fisher Scientific ESRRB Polyclonal Antibody
Mouse와 Rat 시료에 반응하는 ESRRB 폴리클로날 항체로, Western blot과 Immunofluorescence에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. ESRRB 단백질 연구 및 줄기세포 관련 신호전달 연구에 활용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues D(376)YELSQRHEEPRR(388) of mouse ERR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2100260 |
Product Specific Information
PA1-315 detects ERR2 from mouse and rat kidney extracts.
It has been successfully used in Western blot and immunofluorescence procedures.
By Western blot, this antibody detects an ~48 kDa protein representing ERR2 from rat kidney extract.
The PA1-315 immunogen is a synthetic peptide corresponding to residues D(376)YELSQRHEEPRR(388) of mouse ERR2.
This peptide (Cat. # PEP-251) is available for use in neutralization and control experiments.
Target Information
ESRRB (steroid hormone receptor ERR2) plays a role in the maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through FGF and Wnt signaling pathways.
Upon FGF signaling activation, ESRRB interacts with KDM1A by binding to enhancer sites of ELF5 and EOMES, activating transcription and promoting self-renewal of trophoblast stem cells.
ESRRB also regulates expression of multiple rod-specific genes and is required for the survival of this cell type.
Defects in the gene can cause autosomal recessive deafness 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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