Thermo Fisher Scientific PGAM1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.03–0.1 µg/mL

Product Specifications

Product Specific Information

• Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22220-PEP).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

PGAM1 belongs to the phosphoglycerate mutase family. It is an important component of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism and catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway.
PGAM1 is a dimeric enzyme containing, in different tissues, varying proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB).
Mutations in PGAM1 cause muscle phosphoglycerate mutase deficiency, also known as glycogen storage disease X.
Recombinant human PGAM protein, fused to His-tag at N-terminus, was expressed in E. coli and purified using conventional chromatography techniques.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.