Thermo Fisher Scientific GRB2 Polyclonal Antibody
GRB2 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Pig, Rat 반응성. 0.5 mg/mL 농도의 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.05–0.15 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence PRNYVTPVNRNV, from C Terminus of the protein sequence according to NP_002077 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | IgG fraction |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1956467 |
Product Specific Information
- Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX22234-PEP).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GRB2 protein contains one SH2 domain flanked on both sides by an SH3 domain.
In response to EGF, GRB2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos.
The GRB2-Sos complex then binds the EGF receptor.
These interactions play a critical role in the activation of the p21 ras signaling pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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