Thermo Fisher Scientific NELF Polyclonal Antibody
Rabbit polyclonal antibody against human NELF protein. Validated for Western blot at 0.2–1 µg/mL. Recognizes N-terminal region (aa 2–51) of NELF. Suitable for research on neuronal migration and transcription regulation. For research use only.
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Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human NELF (aa 2–51) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607182 |
Product Specific Information
- Peptide sequence: GAAASRRRAL RSEAMSSVAA KVRAARAFGE YLSQSHPENR NGADHLLADA
- Sequence homology:
- Cow: 100%
- Dog: 100%
- Horse: 100%
- Human: 100%
- Mouse: 100%
- Pig: 79%
- Rat: 100%
Target Information
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons, and suppression of transcription elongation. It is found in the peripheral and central nervous system during embryonic development and is highly expressed in adult testis, kidney, and brain. NELF couples NMDA receptor signaling to the nucleus, and its knockdown impairs GnRH neuronal migration in vitro. Mutations in the NELF gene have been associated with idiopathic hypogonadotropic hypogonadism (IHH), a disorder affecting pubertal maturation and reproductive function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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