Thermo Fisher Scientific RENT1 Polyclonal Antibody
UPF1 단백질을 인식하는 Thermo Fisher Scientific의 RENT1 폴리클로날 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. Rabbit IgG 포맷이며, 고순도 친화 크로마토그래피 정제 및 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용 가능합니다.
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- PA5102417
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- pk
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Thermo Fisher Scientific RENT1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UPF1 (Accession Q92900), corresponding to amino acid residues G1063–Q1113 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851822 |
Product Specific Information
Antibody detects endogenous levels of total UPF1.
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. It functions as an ATP-dependent RNA helicase in the cytoplasm and is a component of cytoplasmic P-bodies. Upf1 phosphorylation mediates translation repression accompanying NMD, facilitating mRNA accessibility to the NMD machinery. Other NMD components, Upf2 and Upf3, exhibit perinuclear and nucleocytoplasmic localization, respectively.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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