Thermo Fisher Scientific NFATC1 Polyclonal Antibody
NFATC1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 면역억제제 연구 및 T세포 활성 관련 유전자 발현 연구에 적합. 고순도 Affinity chromatography 정제 항체.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NFATC1 (Accession O95644), corresponding to amino acid residues Y268–A318 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851824 |
Product Specific Information
Antibody detects endogenous levels of total NFAT2.
Target Information
The NFATC1 gene encodes a component of the nuclear factor of activated T cells (NFAT) DNA-binding transcription complex. This complex includes a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. NFAT family proteins play a crucial role in inducible gene transcription during immune responses. NFATC1 acts as a major molecular target for immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified, which may regulate the inducible expression of different cytokine genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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