Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody, Atto 488
TrkB(Extracellular) 단백질을 인식하는 Atto 488 결합 토끼 폴리클로날 항체. 인간, 마우스, 랫트 반응성. IHC(F) 검증됨. 항원 친화 크로마토그래피로 정제되었으며, 형광 검출(501/523 nm)에 적합. 연구용으로 신경계 관련 단백질 분석에 활용 가능.
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Applications
- Immunohistochemistry (Frozen) (IHC (F)): 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)RLEPNSIDPENITE, corresponding to amino acid residues 57–70 of rat TrkB, Extracellular domain |
| Conjugate | Atto™ 488 |
| Excitation / Emission Max | 501 / 523 nm |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at −20 °C.
The reconstituted solution can be stored at 4 °C for up to 1 week. For longer storage, aliquot and store at −20 °C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor receptor family essential for the development and maintenance of the mammalian nervous system.
It is the receptor for brain-derived neurotrophic factor (BDNF), regulating both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, autophosphorylates and activates the MAPK pathway, leading to cell differentiation.
Mutations in TrkB have been associated with obesity and mood disorders.
Alternative splicing produces different isoforms of TrkB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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