Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody, Atto 488

Applications

• Immunohistochemistry (Frozen) (IHC (F)): 1:50

Product Specifications

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at −20 °C.
The reconstituted solution can be stored at 4 °C for up to 1 week. For longer storage, aliquot and store at −20 °C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor receptor family essential for the development and maintenance of the mammalian nervous system.
It is the receptor for brain-derived neurotrophic factor (BDNF), regulating both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, autophosphorylates and activates the MAPK pathway, leading to cell differentiation.
Mutations in TrkB have been associated with obesity and mood disorders.
Alternative splicing produces different isoforms of TrkB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.