Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody

Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature; store at -20°C upon arrival.
• Reconstituted solution can be stored at 4°C (protected from light) for up to 1 week.
• For long-term storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family, crucial for development and maintenance of the mammalian nervous system.
It acts as the receptor for brain-derived neurotrophic factor (BDNF), regulating short-term synaptic functions and long-term potentiation.
TrkB expression is confined to central and peripheral nervous system tissues.
BDNF and NT-3 induce phosphorylation of TrkB gp145, with BDNF eliciting a stronger response.
TrkB signaling leads to cell differentiation via MAPK pathway activation.
Mutations in TrkB are associated with obesity and mood disorders.
Alternate splice variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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