Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody
TrkB (extracellular) rabbit polyclonal antibody로 인간, 마우스, 랫트 반응성. WB, IHC, ICC, Flow 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 비결합형 항체로, 신경영양인자 수용체 연구에 적합. -20°C 보관.
- 카탈로그번호
- ANT-019-xxxxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody
Thermo Fisher Scientific TrkB (extracellular) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 2.5 µg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)RLEPNSIDPENITE, corresponding to amino acid residues 57–70 of rat TrkB, extracellular domain |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
- Ships as lyophilized powder at room temperature; store at -20°C upon arrival.
- Reconstituted solution can be stored at 4°C (protected from light) for up to 1 week.
- For long-term storage, aliquot and keep at -20°C.
- Avoid multiple freeze/thaw cycles.
- Centrifuge all antibody preparations before use (10,000 × g, 5 min).
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family, crucial for development and maintenance of the mammalian nervous system.
It acts as the receptor for brain-derived neurotrophic factor (BDNF), regulating short-term synaptic functions and long-term potentiation.
TrkB expression is confined to central and peripheral nervous system tissues.
BDNF and NT-3 induce phosphorylation of TrkB gp145, with BDNF eliciting a stronger response.
TrkB signaling leads to cell differentiation via MAPK pathway activation.
Mutations in TrkB are associated with obesity and mood disorders.
Alternate splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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