Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI5D10), TrueMAB
NAB2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 적합. Human 시료 반응. Affinity chromatography로 정제된 액상 항체이며 PBS, BSA, glycerol buffer에 보관. -20°C에서 보관, 동결/해동 반복은 피할 것.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of human NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both contain an amino-terminal NAB conserved domain 1 (NCB1) for NGFI-A binding and a carboxy-terminal NCD2 domain responsible for repressor function. NAB2 is localized in the nucleus and may play a role in downregulating NGFI-A activity and controlling processes such as cell division, differentiation, and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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