Thermo Fisher Scientific SIGN-R1 Recombinant Rabbit Monoclonal Antibody (143)
마우스 SIGNR1/CD209b 단백질을 인식하는 재조합 토끼 단일클론 항체. ICC/IF 및 유세포분석에 적합하며, 높은 특이성과 재현성을 제공. 보존제 무첨가 포뮬레이션으로 민감한 실험에 적합. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 143 |
| Immunogen | Recombinant Mouse SIGNR1/CD209b protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785494 |
Additional Formats
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
This antibody has specificity for Mouse SIGNR1/CD209b.
Target Information
SIGNR1 is a type II transmembrane C-type lectin identified as a mouse homologue of human DC-SIGN. It is highly expressed in splenic marginal zone macrophages and lymph node medullary macrophages, where it mediates uptake of dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae.
SIGNR1 physically associates with TLR4/MD2, playing a role in LPS recognition. SIGNR1-deficient mice show defects in complement component C3 catabolism, and SIGNR1 binds directly to complement C1 subcomponent C1q to assemble a non-conventional C3 convertase.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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