Thermo Fisher Scientific SIGN-R1 Recombinant Rabbit Monoclonal Antibody (143)

Applications

Product Specifications

Additional Formats

• PE
• Request custom conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Mouse SIGNR1/CD209b.

Target Information

SIGNR1 is a type II transmembrane C-type lectin identified as a mouse homologue of human DC-SIGN. It is highly expressed in splenic marginal zone macrophages and lymph node medullary macrophages, where it mediates uptake of dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae.
SIGNR1 physically associates with TLR4/MD2, playing a role in LPS recognition. SIGNR1-deficient mice show defects in complement component C3 catabolism, and SIGNR1 binds directly to complement C1 subcomponent C1q to assemble a non-conventional C3 convertase.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.