Thermo Fisher Scientific CD48 Recombinant Rabbit Monoclonal Antibody (341)
마우스 CD48/SLAMF2 단백질을 인식하는 재조합 토끼 모노클로날 항체로 높은 특이성과 민감도를 제공. ICC/IF, Flow Cytometry, ELISA 등에 적합하며, 보존제가 없는 액상 형태로 제공. 장기 보관 시 -20°C에서 냉동 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| Flow Cytometry (Flow) | 1:25–1:100 |
| ELISA | 1:1,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 341 |
| Immunogen | Recombinant Mouse CD48/SLAMF2 protein (Met1–Arg216) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785501 |
Available Conjugated Formats
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody specifically recognizes Mouse CD48/SLAMF2.
Target Information
CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, including CD2, CD58, CD84, CD150, CD229, CD244, and others. These molecules mediate homotypic or heterotypic adhesion through interactions within the Ig family.
CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2. The 2B4–CD48 interaction among NK and NK-T cells regulates proliferation and activation.
CD48 is strongly expressed on lymphocytes and monocytes, weakly on granulocytes, and absent on platelets, fibroblasts, epithelium, and endothelium. It serves as a marker for detecting GPI anchoring defects in paroxysmal nocturnal hemoglobinuria (PNH) and may be involved in allergic airway disease pathology, providing potential therapeutic targets for allergic rhinitis and asthma.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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