Thermo Fisher Scientific RalA Polyclonal Antibody
RalA 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(파라핀) 실험에 적합합니다. 인간, 생쥐, 랫트에 반응하며, 동결건조 형태로 제공됩니다. 연구용으로 세포 신호전달, 증식, 이동 관련 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:4,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human RalA conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity of this antibody: Ral-A
Target Information
RalA is a multifunctional GTPase involved in diverse cellular processes such as gene expression, cell migration, proliferation, oncogenic transformation, and membrane trafficking. It functions as a GTP sensor for exocytosis of dense core vesicles and is essential for cytokinesis by tethering the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. It also modulates LPAR1 signaling by competing with GRK2, influencing receptor signaling properties. RalA is required for anchorage-independent proliferation of transformed cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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