Thermo Fisher Scientific RhoA Polyclonal Antibody
RhoA 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. WB 및 IHC에 적합하며, 인간, 마우스, 랫 등 다양한 종에 반응합니다. 합성 펩타이드(aa 100–150)를 면역원으로 사용하며, 동결건조 형태로 제공됩니다.
- 카탈로그번호
- OSR00266W-100UL
- 판매단위
- pk
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Thermo Fisher Scientific RhoA Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 100–150 of human RhoA conjugated to a blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in many species including rat, mouse, chicken, dog, bovine, frog, zebrafish, and orangutan.
- Specificity of this antibody: RhoA.
Target Information
RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. It is involved in a microtubule-dependent signal required for myosin contractile ring formation during cytokinesis and plays an essential role in cleavage furrow formation.
RhoA is required for apical junction formation in keratinocyte adhesion and serves as a target for the yopT cysteine peptidase from Yersinia pestis and Yersinia pseudotuberculosis.
It stimulates PKN2 kinase activity and may activate PLCE1. Activated by ARHGEF2, RhoA promotes GDP-GTP exchange and is essential for SPATA13-mediated regulation of cell migration and adhesion assembly/disassembly.
The MEMO1-RHOA-DIAPH1 signaling pathway is important in ERBB2-dependent stabilization of microtubules at the cell cortex, controlling APC and CLASP2 localization to the membrane via GSK3B regulation. Membrane-bound APC enables MACF1 membrane localization, required for microtubule capture and stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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