Thermo Fisher Scientific RhoB Polyclonal Antibody
RhoB 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트에서 반응하며, 세포 접착 및 성장 인자 신호 연구에 활용됩니다. 동결건조 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human Rho-related GTP-binding protein RhoB conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and rat.
- Specificity of this antibody: RhoB.
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it affects cell adhesion and growth factor signaling in transformed cells.
RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. It is also required for stability and nuclear trafficking of AKT1/AKT, promoting endothelial cell survival during vascular development.
RhoB serves as a tumor suppressor — deletion of RhoB causes tumor formation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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