Thermo Fisher Scientific RhoB Polyclonal Antibody
Rabbit polyclonal antibody targeting human RhoB protein for WB and IHC applications. Lyophilized form, reconstitutable in sterile water. Suitable for apoptosis and cell signaling research. Stable storage at 4°C or -20°C with glycerol addition. For rese...
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Thermo Fisher Scientific RhoB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human Rho-related GTP-binding protein RhoB |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2179096 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute in 100 µL of sterile water.
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells following DNA damage. Although not essential for development, it influences cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in EGF receptor trafficking from late endosomes to lysosomes. It also contributes to AKT1/AKT stability and nuclear trafficking, promoting endothelial cell survival during vascular development. RhoB acts as a tumor suppressor—its deletion can lead to tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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