Thermo Fisher Scientific P4HB Recombinant Rabbit Monoclonal Antibody (JE54-98)
P4HB 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE54-98 |
| Immunogen | Recombinant protein within Human P4HB aa 360–508 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2890482 |
Target Information
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins.
Inside the cell, PDI forms and rearranges disulfide bonds of nascent proteins.
At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins, while at low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may participate with other chaperones in structural modification of the TG precursor in hormone biogenesis.
It also acts as a structural subunit of enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
As a receptor for LGALS9, P4HB is retained at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering redox state, and enhancing cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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