Thermo Fisher Scientific CD18 Monoclonal Antibody (TA-4)
CD18 단백질을 인식하는 TA-4 모노클론 항체로, 인간 및 랫트 시료에 반응합니다. ICC/IF, Flow Cytometry, ELISA, Neutralization 등 다양한 응용 가능. Rat β2 Integrin을 면역원으로 사용하며, LAL 시험을 통해 낮은 엔도톡신 수준 확인. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| ELISA | - | View 1 publication |
| Neutralization (Neu) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TA-4 |
| Immunogen | Rat beta2 Integrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223589 |
Product Specific Information
MA1807 targets CD18 in FACS applications and shows reactivity with Rat samples.
The immunogen is rat beta2 Integrin.
MA1807 detects CD18 with a predicted molecular weight of approximately 83 kDa.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains ≤10 EU/mg endotoxin concentration.
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
It combines with CD11a–d integrins to form β2 heterodimers (LFA-1, Mac-1, CR3, CD11d/CD18), which mediate cell adhesion and signaling.
Deficiency of CD18 leads to leukocyte adhesion deficiency type I (LAD1) and related immune disorders.
CD18 also serves as a receptor for Mannheimia haemolytica leukotoxin, mediating cytolysis.
Two transcript variants encoding CD18 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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