Thermo Fisher Scientific AKAP3 Polyclonal Antibody
AKAP3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 사람 및 생쥐 시료에 반응합니다. 면역세포염색(ICC/IF)에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며 -20°C에서 보관합니다.
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human AKAP3 (amino acids 212–234, UniProt ID: O75969-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635228 |
Product Specific Information
This antibody detects endogenous levels of total AKAP3 protein.
Target Information
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by compartmentalization of the kinase to specific cellular sites. The R subunit (RII) of PKA interacts with A-kinase anchoring proteins (AKAPs) to maintain localization.
AKAP3 (also known as AKAP110, FSP95, PRKA3, SOB1) binds both PKA and PDE4A, functioning as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions.
Expression of AKAP3 is restricted to testis under normal conditions, where bicarbonate stimulates its tyrosine phosphorylation, enhancing PKA recruitment.
AKAP3 shows high expression in epithelial ovarian cancer (EOC), demonstrating tumor-restricted expression and association with poorer survival, suggesting its potential as a target for antigen-specific immunotherapy in EOC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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