Thermo Fisher Scientific TNFAIP8 Polyclonal Antibody
TNFAIP8 단백질을 인식하는 Rabbit Polyclonal 항체로, Human과 Mouse 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human TFIP8 (AA 54–76, total length 198) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635231 |
Product Specific Information
This antibody detects endogenous levels of total TNFAIP8 protein.
Target Information
TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2, or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF. Its induction by TNF depends on NFkappa B activation. TNFalpha-IP 8 negatively regulates apoptosis and may contribute to tumor progression by inhibiting caspase-8 activity, thereby preventing BID cleavage and caspase-3 activation during TNF-mediated apoptosis. It is highly expressed in thymus, bone marrow, lymph node, spleen, thyroid, placenta, and various tumor tissues, as well as fetal lung, liver, and kidney. Three isoforms are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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